Chloramphenicol

    Chloramphenicol :

    Antibiotic ID : UD0018

    Full Name : Chloramphenicol

    Synonyms : Chloromycetin, Chlornitromycin, Levomycetin, Detreomycin, Globenicol, Halomycetin, Aquamycetin, Chloramficin, Chloramfilin

    Class : Beta Lactum

    Chemical Description :

    Molecular Formula : C11H12C12N2O5

    Molecular Weight : 323.12938

    InChIKey : WIIZWVCIJKGZOK-RKDXNWHRSA-N

    IUPAC Name : 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide

    Structural Description :

    Canonical SMILES : C1=CC(=CC=C1C(C(CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]

    Isomeric SMILES : C1=CC(=CC=C1[C@H]([C@@H](CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]

    2D Structure : 2D

    3D Structure : 3D

    SDF : SDF file

    Fuctional Description :

    Chloramphenicol Target : An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic(MeSH).

    KEGG : D00104

    DRUG BANK : DB00446

    Pub Chem CID : 5959

    Antibiotics Resistance Reports :

    Upregulators :

    Genes : cat1, cmlA, catII, catIII, cml, mfdAmfdA

    Downregulators :

    Genetic element : Loss of plasmid correlated to loss of antibiotic resistance

    Note : NA* - Not Available

    Bibliography :