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Norfloxacin
Norfloxacin :
Antibiotic ID :
UD0033
Full Name :
Norfloxacin
Synonyms :
Noroxin, Chibroxin, Baccidal, Sebercim, 70458-96-7, Norfloxacine, MK-366, Norfloxacino, Norfloxacinum
Class :
Beta Lactum
Chemical Description :
Molecular Formula :
C
16
H
18
FN
3
O
3
Molecular Weight :
319.330823
InChIKey :
OGJPXUAPXNRGGI-UHFFFAOYSA-N
IUPAC Name :
1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
Structural Description :
Canonical SMILES :
CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O
Isomeric SMILES :
NA
2D Structure :
2D
3D Structure :
3D
SDF :
SDF file
Fuctional Description :
Norfloxacin Target :
A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE
(MeSH)
.
KEGG :
D00210
DRUG BANK :
DB01059
Pub Chem CID :
4539
Antibiotics Resistance Reports :
Upregulators :
Protien :
BC4707
Downregulators :
NA
Note :
NA* - Not Available
Bibliography :
Multidrug Resistance and Plasmid Patterns of Escherichia coli O157 and Other E. coli Isolated from Diarrhoeal Stools and Surface Waters from Some Selected Sources in Zaria, Nigeria
, Chigor V. N., Umoh V. J., Smith S. I., Igbinosa E. O., and Okoh A. I.,
International Journal of Environmental Research and Public Health
, 2009,
7
:3831-3841.
PMID:
21139863
BC4707 is a major facilitator superfamily multidrug resistance transport protein from Bacillus cereus implicated in fluoroquinolone tolerance
, Simm R, Vörös A, Ekman JV, Sødring M, Nes I, Kroeger JK, Saidijam M, Bettaney KE, Henderson PJ, Salkinoja-Salonen M, Kolstø AB.
, PLoS One
, 2012,
7
(5):e36720.
PMID:
22615800