Rifampin

    Rifampin :

    Antibiotic ID : UD0038

    Full Name : Rifampin

    Synonyms : Rifampicin, Rifadin, Rimactane, Rimactan, Rifamycin AMP, Rifampicinum, Riforal, Tubocin, Rifa

    Class : Beta Lactum

    Chemical Description :

    Molecular Formula : C43H58N4O12

    Molecular Weight : 822.94022

    InChIKey : FZYOVNIOYYPUPY-ZTWDQPHTSA-N

    IUPAC Name : NA

    Structural Description :

    Canonical SMILES : CC1C=CC=C(C(=O)NC2=C(C3=C(C(=C4C(=C3C(=O)C2=CNN5CCN(CC5)C)C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)C

    Isomeric SMILES : C[C@H]1/C=C/C=C(\C(=O)NC\2=C(C3=C(C(=C4C(=C3C(=O)/C2=C/NN5CCN(CC5)C)C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)/C

    2D Structure : 2D

    3D Structure : 3D

    SDF : SDF file

    Fuctional Description :

    Rifampin Target : A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms (MeSH).

    KEGG : D00211

    DRUG BANK : DB01045

    Pub Chem CID : 5381226

    Antibiotics Resistance Reports :

    Upregulators :

    Gene : mfdA

    Downregulators : NA

    Note : NA* - Not Available

    Bibliography :