Tetracycline

    Tetracycline :

    Antibiotic ID : UD0044

    Full Name : Tetracycline

    Synonyms : Tetracyclinum, Achromycin, Tsiklomitsin, Abramycin, Tetraciclina, Deschlorobiomycin, Hostacyclin, Tetraverine, Tsiklomistsin

    Class : Beta Lactum

    Chemical Description :

    Molecular Formula : C22H24N2O8

    Molecular Weight : 444.43456

    InChIKey : NWXMGUDVXFXRIG-WESIUVDSSA-N

    IUPAC Name : (4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide

    Structural Description :

    Canonical SMILES : CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O

    Isomeric SMILES : C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O

    2D Structure : 2D

    3D Structure : 3D

    SDF : SDF file

    Fuctional Description :

    Tetracycline Target : A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis (MeSh)

    KEGG : D00201

    DRUG BANK : DB00759

    Pub Chem CID : 54675776

    Antibiotics Resistance Reports :

    Upregulators :

    Enzyme : CTX-Mβ-lactamases

    External Effect : Quartz attachment

    Internal Effect : E. coli strains (B2-O25b-ST131-CTX-M-15)

    Gene : tetA, tetB, tetC, tetD, tetE, tetG, mfdA

    Mutation : C1058G of 16S rRNA

    Downregulators :

    External Effect : Loss of plasmid correlated to loss of antibiotic resistance

    Note : NA* - Not Available

    Bibliography :