Trimethoprim

    Trimethoprim :

    Antibiotic ID : UD0047

    Full Name : Trimethoprim

    Synonyms : Proloprim, Trimpex, Bactramin, Monotrim, Monotrimin, 738-70-5, Syraprim, Trimopan, Sulfamethoprim

    Class : Beta Lactum

    Chemical Description :

    Molecular Formula : C14H18N4O3

    Molecular Weight : 290.31772

    InChIKey : IEDVJHCEMCRBQM-UHFFFAOYSA-N

    IUPAC Name : 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine

    Structural Description :

    Canonical SMILES : COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N

    Isomeric SMILES : NA

    2D Structure : 2D

    3D Structure : 3D

    SDF : SDF file

    Fuctional Description :

    Trimethoprim Target : A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported (MeSh)

    KEGG : D00145

    DRUG BANK : DB00440

    Pub Chem CID : 5578

    Antibiotics Resistance Reports :

    Upregulators :

    Enzyme : CTX-Mβ-lactamases

    Gene : dfrA1, dfrA9, dfrA12, dfrA13, dfr7, dfr17, dhfrI, dhfrV, dhfrXIII

    Downregulators : NA

    Note : NA* - Not Available

    Bibliography :