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Gene
acrA :
Gene ID :
UG0034
Summary :
Full Name :
acrA multidrug efflux system [ Escherichia coli str. K-12 substr. MG1655 ]
Symbol :
acrA
Also known as :
ECK0457; JW0452; lir; Mb; mbl; mtcA; nbsA; sipB
Gene description :
multidrug efflux system
Gene Position :
484426..485619
Gene strain :
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Transcription Factor :
acrA
Lineage :
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia
Antibiotic Resistance Description :
Mutation :
A968T
Mechanism :
Transcription Factor
Antibiotic :
Acriflavin
,
Aminoglycoside
,
Beta Lactam
,
Glycylcycline
,
Macrolide
Functional Description :
NCBI Gene ID :
945112
Patric :
32116079
GO :
acrA
CDD :
223914
DEG :
NA
Ecocyc :
EG11703
KEGG :
b0463
Uniprot :
P0AE06
Genomic context :
Gene – Protien :
NP_414996.1
Sequence :
Fasta
NA : Not available.
Bibliography :
Interplay between efflux pumps may provide either additive or multiplicative effects on drug resistance
, Lee A, Mao W, Warren MS, Mistry A, Hoshino K, Okumura R, Ishida H, Lomovskaya O.
, Journal of Bacteriology
, 2000,
182
(11):3142-50.
PMID:
10809693.
Conserved small protein associates with the multidrug efflux pump AcrB and differentially affects antibiotic resistance
, Hobbs EC, Yin X, Paul BJ, Astarita JL, Storz G
, Proceedings of the National Academy of Sciences USA
, 2012,
109
(41):16696-701.
PMID:
23010927.
Evolutionary potential, cross-stress behavior and the genetic basis of acquired stress resistance in Escherichia coli
, Martin Dragosits, Vadim Mozhayskiy, Semarhy Quinones-Soto, Jiyeon Parkand Ilias Tagkopoulos
, Molecular Systems Biology
, 2012,
9
:643.
PMID:
23385483.