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Gene

Gene ID : UG0035

Full Name : acrB multidrug efflux system protein [ Escherichia coli str. K-12 substr. MG1655 ]

Symbol : acrB

Also known as : acrE; ECK0456; JW0451

Gene description : multidrug efflux system protein

Gene Position : 481254..484403

Gene strain : Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)

Transcription Factor : acrB

Lineage : Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia

Mutation : G480665A

Mechanism : Single Nuclieotide Polymorphism

Antibiotic : Acriflavin, Aminoglycoside, Beta Lactam, Glycylcycline, Macrolide

NCBI Gene ID : 945108

Patric : 32116077

GO : acrB

CDD : 129993

DEG : NA

Ecocyc : EG11704

KEGG : b0462

Uniprot : P31224

Gene – Protien : NP_414995.1

Sequence : Fasta

NA : Not available.

Interplay between efflux pumps may provide either additive or multiplicative effects on drug resistance, Lee A, Mao W, Warren MS, Mistry A, Hoshino K, Okumura R, Ishida H, Lomovskaya O. , Journal of Bacteriology, 2000, 182(11):3142-50. PMID: 10809693.

Conserved small protein associates with the multidrug efflux pump AcrB and differentially affects antibiotic resistance, Hobbs EC, Yin X, Paul BJ, Astarita JL, Storz G , Proceedings of the National Academy of Sciences USA, 2012, 109(41):16696-701. PMID: 23010927.

Evolution combined with genomic study elucidates genetic bases of isobutanol tolerance in Escherichia coli, Jeremy J Minty, Ann A Lesnefsky, Fengming Lin, Yu Chen, Ted A Zaroff, Artur B Veloso, Bin Xie, Catie A McConnell, Rebecca J Ward, Donald R Schwartz, Jean-Marie Rouillard, Yuan Gao, Erdogan Gulari, Xiaoxia Nina Lin, Microbial Cell Factories, 2011, 10:18. PMID: 21435272.