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Gene
alaS :
Gene ID :
UG0040
Summary :
Full Name :
alaS alanyl-tRNA synthetase [ Escherichia coli str. K-12 substr. MG1655 ]
Symbol :
alaS
Also known as :
act; ala-act; ECK2692; JW2667; lovB
Gene description :
alanyl-tRNA synthetase
Gene Position :
2819381..2822011
Gene strain :
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Transcription Factor :
alaS
Lineage :
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia
Antibiotic Resistance Description :
Mutation :
Mutations in ribosomal proteins S5 and S20 partially suppresses the temperature sensitive growth defect of an alaS mutation.
Mechanism :
Transcription Factor
Antibiotic :
Novobiocin
Functional Description :
NCBI Gene ID :
947175
Patric :
32120790
GO :
alaS
CDD :
237551
DEG :
NA
Ecocyc :
EG10034
KEGG :
b2697
Uniprot :
P00957
Genomic context :
Gene – Protien :
NP_417177.1
Sequence :
Fasta
NA : Not available.
Bibliography :
tRNA synthetase mutants of Escherichia coli K-12 are resistant to the gyrase inhibitor novobiocin
, Jovanovic M, Lilic M, Janjusevic R, Jovanovic G, Savic DJ.
, , Journal of Bacteriology
, 1999,
181
(9):2979-83.
PMID:
10217798.
Suppression of temperature-sensitive aminoacyl-tRNA synthetase mutations by ribosomal mutations: a possible mechanism
, Buckel P, Piepersberg W, Böck A.
, Molecular Genetics and Genomics
, 1976,
149
(1):51-61.
PMID:
796671.