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Gene
gyrA :
Gene ID :
UG0024
Summary :
Full Name :
gyrA DNA gyrase (type II topoisomerase), subunit A [ Escherichia coli str. K-12 substr. MG1655 ]
Symbol :
gyrA
Also known as :
ECK2223; hisW; JW2225; nalA; nfxA; norA; parD
Gene description :
DNA gyrase (type II topoisomerase), subunit A
Gene Position :
2336793..2339420
Gene strain :
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Transcription Factor :
ECK120000416
Lineage :
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia
Antibiotic Resistance Description :
Mutation :
Mutations in the genes encoding drug target DNA gyrase
Mechanism :
NA
Antibiotic :
Quinolones
Functional Description :
NCBI Gene ID :
946614
Patric :
NA
GO :
1384880517
CDD :
233256
DEG :
DEG10180351
Ecocyc :
EG10423
KEGG :
b2231
Uniprot :
Q0QCL9
Genomic context :
Gene – Protien :
NP_416734.1
Sequence :
Fasta
NA : Not available.
Bibliography :
Temporal interplay between efflux pumps and target mutations in development of antibiotic resistance in Escherichia coli
, Singh R, Swick MC, Ledesma KR, Yang Z, Hu M, Zechiedrich L, Tam VH.
, Antimicrobial Agents and Chemotherapy
, 2012,
56
(4) :1680-5.
PMID:
22232279.