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Gene
parC :
Gene ID :
UG0026
Summary :
Full Name :
parC DNA topoisomerase IV, subunit A [ Escherichia coli str. K-12 substr. MG1655 ]
Symbol :
parC
Also known as :
ECK3010; JW2987
Gene description :
DNA topoisomerase IV, subunit A
Gene Position :
3163715..3165973
Gene strain :
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Transcription Factor :
ECK120000679
Lineage :
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia
Antibiotic Resistance Description :
Mutation :
Mutations in the genes encoding drug target Topoisomerase IV
Mechanism :
Inhibited by quinolones.
Antibiotic :
Quinolones
Functional Description :
NCBI Gene ID :
947499
Patric :
32121452
GO :
parC
CDD :
214660
DEG :
DEG10180449
Ecocyc :
EG10686
KEGG :
b3019
Uniprot :
P0AFI2
Genomic context :
Gene – Protien :
NP_417491.1
Sequence :
Fasta
NA : Not available.
Bibliography :
Temporal interplay between efflux pumps and target mutations in development of antibiotic resistance in Escherichia coli
, Singh R, Swick MC, Ledesma KR, Yang Z, Hu M, Zechiedrich L, Tam VH.
, Antimicrobial Agents and Chemotherapy
, 2012,
56
(4) :1680-5.
PMID:
22232279.